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Biomimetic ceramic composites

发布时间:2019-09-26    作者:        来源:       浏览次数:     打印








Biomimetic ceramic composites for chairside CAD/CAM dental restorations

Machinable ceramics which could be used as a chairside CAD/CAM material that only needs minutes for dental treatment are highly desirable. In this talk, we will discuss the potential of a nacre-like alumina/UDMA composite with brick & mortar structure for such an application.



Investigating bactericidal mechanisms for contact killing nanotopographies using electron tomography and quantitative proteomic analysis

Given the significant failure rates in treating medical device-associated infections with antibiotics, novel approaches are urgently needed to prevent the development of pathogenic biofilms on titanium devices. Inspired by nature, we aim to generate titanium nanostructure arrays that efficiently kill bacteria upon contact, via physical rupture of the bacterial envelope. We hope to apply this technology to the rational design of next generation, anti-infective implants. A simple thermal oxidation was used to create bio-inspired titanium dioxide nanostructure arrays on titanium alloy surfaces. The antibacterial performance of nanostructured surfaces was determined by advanced fluorescence microscopy and metabolic indicator assays.




Rational design and fabrication of antimicrobial polymer surfaces based on biomimetic nanotopography

We aim to understand how the differences in topography affect the bactericidal properties experimentally and theoretically. Two nanopatterning methods (colloidal lithography and anodisation/hot embossing) were used to design different polymeric nanopillars on polyethylene terephthalate (PET) substrate that differs in terms of sharpness and density of the nanopillars. Ti was found that the sharper and denser nanopillars had the best bactericidal performance when compared to the other nanostructured surfaces.




Synergistic antimicrobial implant surfaces functionlised with enzyme and peptides


The approach taken in this study is to functionalise TiO2 nanowires with the bactericidal enzyme, lysostaphin. Such a multi-faceted, synergistic approach, whereby Gram-negative cells are mechanically killed and Gram-positive cells are chemically killed, has led to the generation of a multi-functional bactericidal surface which has the potential to be used in medical implants.

报告人简介:Prof Bo Su, Head of Bioengineering Materials Research Department, Center for Applied Clinical and Material Sciences, School of Dentistry, University of Bristol. His main research interests include micron and nano-fabrication of dental materials, dental biomimetic composites, dental and orthopaedic implants, etc. In Biomaterials, Dental Materials and other international first-class science. More than 100 papers have been published in academic journals, 2 international patents have been awarded, and more than 10 scientific research projects have been presided over.